Journal of ISSN: 2373-6410JNSK

Neurology & Stroke
Editorial
Volume 2 Issue 4 - 2015
A Need for Genetic Profiles of Alzheimer’s Disease Patients
Abdelaziz Ghanemi1, 2, 3*
1Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences , Kunming, Yunnan 650223, PR China
2 Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China
3University of Chinese Academy of Sciences, Beijing, China
Received: July 19, 2015| Published: July 20, 2015
*Corresponding author: Abdelaziz Ghanemi, Key Laboratory of Animal Models and Human Disease Mechanisms, Kunming Institute of Zoology Chinese Academy of Sciences, No. 32 Jiao chang dong lu, Kunming 650223, China, E-mail: @
Citation: Ghanemi A (2015) A Need for Genetic Profiles of Alzheimer’s Disease Patients. J Neurol Stroke 2(4): 00062. DOI: 10.15406/jnsk.2015.02.00063 DOI: 10.15406/jnsk.2015.02.00063

Editorial

Alzheimer’s disease (AD) is among the most known neurodegenerative disease [1] and represents the most prevalent dementia [2].  AD has been studied from different angles including biochemistry, proteomics, behavior, environmental factors and genetic risks [3]. However, genetic factors seem to be limited due to the low percentage of AD cases in which genetics has been involved.

However, establishing a genetic profile of AD patients followed with statistical analysis of the obtained results might provide data allowing us to link specific genes or group of genes to AD. Such approaches could lie on the current understanding of the genetic aspects of AD as a starting point. Such project could be a part of the brain projects within a context of international collaborations toward a genetic explanation of AD that will allow us to elucidate some of the unknown underlying pathways, use the identified genes to build animals models of AD [4] and eventually test some therapeutic candidates on the built animal models.

Importantly, those genes identify as related to AD risk or the pathways related or controlled by those genes could represent therapeutic targets toward developing new AD treatments if those genetic data are combined with the pharmacology [5] (including the traditional medicines [6] and pharmacognosy [7]), toxicology [8], chemistry [9], zoology [10] and cell culture methods [11,12].

Acknowledgement

Abdelaziz Ghanemi is a recipient of a 2013 CAS-TWAS President's Postgraduate Fellowship.

References

  1. Crawford F, Freeman MJ, Schinka J, Abdullah L, Gold M, et al. (2000) The cystatin C gene as a novel genetic risk factor for late onset Alzheimer's disease. Neurobiology of Aging 21(Suppl 1): 204.
  2. Ghanemi A (2015) Alzheimer’s disease therapies: Selected advances and future perspectives. Alexandria Journal of Medicine 51(1): 1-3.
  3. Poduslo SE, Drigalenko E, Yin X (2000) The genetics of late onset Alzheimer's disease. Neurobiology of Aging 21(Suppl 1): 204.
  4. Ghanemi A (2014) Animal models of Alzheimer's disease: Limits and challenges. NPG Neurologie - Psychiatrie – Gériatrie 14(84): 303-305.
  5. Ghanemi A (2014) Is mapping borders between pharmacology and toxicology a necessity? Saudi Pharm J 22(6): 489-490.
  6. Ghanemi A, Boubertakh B (2015) Shorter and sturdier bridges between traditional Chinese medicines and modern pharmacology. Saudi Pharm J 23(3): 330-332.
  7. Ghanemi A (2015) How important is pharmacognosy for doctors and dentists? Saudi Dent J 27(1): 1-2.
  8. Ghanemi A (2014) How to define a pharmacological or a toxic food? Alexandria Journal of Medicine doi:10.1016/j.ajme.2014.06.004.
  9. Ghanemi A (2014) Biological properties and perspective applications of “Bio-neuter” chemicals? Saudi Pharm J 22(1): 1-2.
  10. Ghanemi A (2015) How to map the bridges between zoology and pharmacology? The Journal of Basic & Applied Zoology doi:10.1016/j.jobaz.2014.12.003.
  11. Ghanemi A (2014) Cell cultures in drug development: Applications, challenges and limitations. Saudi Pharm J doi:10.1016/j.jsps.2014.04.002.
  12. Carter M, Shieh JC (2010) Cell Culture Techniques. In:  12.       Carter M, Shieh JC (Eds.), Guide to Research Techniques in Neuroscience. (2nd edn), Academic Press, San Diego, California, USA, pp. 295-310.
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