Journal of ISSN: 2376-0060JLPRR

Lung, Pulmonary & Respiratory Research
Editorial
Volume 1 Issue 1 - 2014
Hematological Manifestations in Patients with Newly Diagnosed Pulmonary Tuberculosis
Attapon Cheepsattayakorn1* and Ruangrong Cheepsattayakorn2
1Department of Disease Control, 10th Zonal Tuberculosis and Chest Disease Center, Thailand
2Department of Pathology, Chiang Mai University, Thailand
Received: August 22, 2014 | Published: August 23, 2014
*Corresponding author: Attapon Cheepsattayakorn, Department of Disease Control, 143 Sridornchai Road Changklan Muang, Chiang Mai 50100, Thailand, Tel: 66-53-140767; Fax: 66-53-140773; Email: @
Citation: Cheepsattayakorn A, Cheepsattayakorn R (2014) Hematological Manifestations in Patients with Newly Diagnosed Pulmonary Tuberculosis. J Lung Pulm Respir Res 1(1): 00005. http://dx.doi.org/10.15406/jlprr.2014.01.00005

Introduction

Tuberculosis (TB), particularly TB is still a major public health problem of the world. Pulmonary eosinophilia [1,2], Hypereosinophilia [3], Reactivethrombocytosis [4-6], Thrombocytopenia [7], Disseminated intravascular coagulation [8], Deep venous thrombosis [9], Henoch-Schonlein purpura [10-12], Leukocytosis with neutrophilia [7,13], Lymphocytopenia [11,14], Monocytopenia, Lymphocytosis, Monocytosis [7], Severe leukopenia [7,15], Idiopathic thrombocytopenic purpura [16,17], Pancytopenia [7,13,18] Could be found in patients with newly diagnosed pulmonary TB.

Hereditary Glucose-6-Phosphate Dehydrogenase Deficiency and Pulmonary Tuberculosis

A study in Azerbaijan, a state of former Soviet Union demonstrated that the etiological role of this abnormality as a genetic marker for pulmonary TB was 14% in associated pulmonary tuberculosis and alcoholism, it grew to 18% [19]. Another study in this region also showed a high incidence of this hereditary disorder among patients with pulmonary TB [20].

Hematological Malignancies and Pulmonary Tuberculosis

Pulmonary military TB have been reported among patients with acute myeloid leukemia, chronic myeloid leukemia, acute lymphocytic leukemia, Hodgkin’s disease, T-cell lymphoma and myelodysplastic syndrome [21-23].

Sickle Cell Disease and Tuberculosis

Sickle cell disease was reported in patients with TB in France and Africa [24-26]. Many reports suggest that severe pulmonary TB in association with reduced tissue cellular reaction may cause blood dyscrasias. Anemia was present in 32% of cases. Leucopenia with neutropenia and lymphopenia was seen in 15% of patients with very severe clinical TB. Active tuberculosis was associated with significant reductions in absolute numbers of B lymphocytes, but there were no significant differences in total T8-cell counts [15]. There was reversal of T4//T8 ratio due to T4 lymphopenia. A study in Nigeria showed that 95% had normochromic picture while 5% demonstrated anisopoikilocytosis and polychromasia. The mean platelet counts did not change significantly from the initial value [27].

References

  1. Vijayan VK, Reetha AM, Jawahar MS, Sankaran K, Prabhakar R (1992) Pulmonary eosinophilia in pulmonary tuberculosis. Chest 101(6): 1708-1709.
  2. Stepanian IE, Lovacheva OV, Dmitrieva LI, Evgushchenko GV (2006) Differential diagnosis of tuberculosis of respiratory organs and pulmonary eosinophilia. Probl Tuberk Bolezn Legk 8: 13-17.
  3. Ray D, Abel R (1994) Hypereosinophilia in association with pulmonary tuberculosis in a rural population in south India. Indian J Med Res 100: 219-222.
  4. Baynes RD, Bothwell TH, Flax H, McDonald TP, Atkinson P, et al. (1987) Reactive thrombocytosis in pulmonary tuberculosis. J Clin Pathol 40(6): 676-679.
  5. Unsal E, Aksaray S, Koksal D, Sipit T (2005) Potential role interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis. Postgrad Med J 81(959): 604-607.
  6. Turken O, Kunter E, Sezer M, Solmazgul E, Cerrahoglu K, et al. (2002) Hemostatic changes in active pulmonary tuberculosis. Int J Tuberc Lung Dis 6(10): 927-932.
  7. Singh KJ, Ahluwalia G, Sharma SK, Saxena R, Chaudhary VP, et al. (2001) Significance of hematological manifestations in patients with tuberculosis. J Assoc Physicians India 49: 788, 790-794.
  8. Fujita M, Kunitake R, Nagano Y, Maeda F (1997) Disseminated intravascular coagulation associated with pulmonary tuberculosis. Intern Med 36(3): 218-220.
  9. Casanova-Roman M, Rios J, Sanchez-Porto A, Casanova-Bellido M (2002) Deep venous thrombosis associated with pulmonary tuberculosis and transient protein S deficiency. Scand J Infect Dis 34(5): 393-394.
  10. Kitamura H, Shimizu K, Takeda H, Tai H, Ito Y, et al. (2007) A case of Henoch-Scholein purpura nephritis in pulmonary tuberculosis. Am J Med Sci 333(2): 117-121.
  11. Mishima Y, Takeuchi M, Kamisaka K, Okada C, Tada A, et al. (1994) Henoch-Sholein purpura associated with pulmonary tuberculosis. Kekkaku 69(1): 21-25.
  12. Han BG, Choi SO, Shin SJ, Kim HY, Jung SH, et al. (1995) A case of Henoch-Schonlein purpura in disseminated tuberculosis. Korean J Intern Med 10(1): 54-59.
  13. Bozoky G, Ruby E, Goher I, Toth J, Mohos A (1997) Hematologic abnormalities in pulmonary tuberculosis. Orv Hetil 138(17): 1053-1056.
  14. Pilheu JA, De Salvo MC, Gonzalez J, Rey D, Elias MC, et al. (1997) CD4+ T-lymphocytopenia in severe pulmonary tuberculosis without evidence of human immunodeficiency virus infection. Int J Tuberc Dis 1(5): 422-426.
  15. Mihaltan F, Lupu A, Ungureanu D, Halic G, Badea C, et al. (2001) Association of atypical pulmonary TB, polyserositis, severe leucopenia and panniculitis. Case report. Pneumologia 50(3): 177-181.
  16. Yasuda Y, Matsubara Y, Watanabe S, Hatakenaka R, Funatsu T, et al. (1994) A case of intractable pulmonary tuberculosis complicated by idiopathic thrombocytopenic purpura (IPT). Nihon Kyobu Geka Gakkai Zasshi 42(12): 2301-2305.
  17. Tsuro K, Kojima H, Mitoro A, Yoshiji H, Fujimoto M, et al. (2006) Immune thrombocytopenic purpura associated with pulmonary tuberculosis. Intern Med 45(11): 739-742.
  18. Francois B, Clavel M, Trimoreau F, Desachy A, Slaouti P, et al. (1998) Pancytopenia and pulmonary tuberculosis. Significance of a hemophagocyticsyndrome. Rev Mal Respir 15(5): 668-670.
  19. Insanov AB, Abdullaev FM, Ragimov AA, Talybova AM, Umniashkin AA (1989) Pulmonary tuberculosis in patients with hereditary glucose-6-phosphate dehydrgenase deficiency. Ter Arkh 61(11): 75-77.
  20. Insanov AB, Abdullaev FM, Kotsobashvili LIa, Umniashkin AA (1993) Gene geography of hereditary glucose-6-phosphate dehydrogenase deficiency an pulmonary tuberculosis in Azerbaijan. Probl Tuberk (2): 5-8.
  21. Uetake T, Sakamaki T, Onozawa Y, Kimura H, Fukayama M (1990) Clinicopathological study of military tuberculosis in patients with hematologic disease. Kekkaku 65(4): 273-283.
  22. Adzic T (2004) Pulmonary tuberculosis in patients with hematological malignancies. Med Pregl 57: 65-68.
  23. Kim HC, Goo JM, Kim HB, Lee JW, Seo JB, et al. (2002) Tuberculosis in patients with myelodysplastic syndromes. Clin Radiol 57(5): 408-414.
  24. Lionnet F, Bachmeyer C, Sloma I, Rossier A, Thioliere B, et al. (2007) Tuberculosis in adult patients with sickle cell disease. J Infect 55(5): 439-444.
  25. Koffi N, Koffi KG, Sangare A (2000) Prevalence of tuberculosis in sickle cell Africans. Rev Pneumol Clin 56(3): 219-220.
  26. Kehinde AO, Olaniyi JA, Fakunle EE (2006) Case report: extra-pulmonary tuberculosis in sickle cell disease. Afr J Med Med Sci 35(3): 381-384.
  27. Dosumu EA (2001) Pattern of some hematological indices in newly diagnosed pulmonary tuberculosis cases in Iwo, Nigeria: diagnostic and therapeutic implications. Niger J Med 10(1): 18-20.
© 2014-2016 MedCrave Group, All rights reserved. No part of this content may be reproduced or transmitted in any form or by any means as per the standard guidelines of fair use.
Creative Commons License Open Access by MedCrave Group is licensed under a Creative Commons Attribution 4.0 International License.
Based on a work at http://medcraveonline.com
Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version | Opera |Privacy Policy