ISSN: 2373-6372GHOA

Gastroenterology & Hepatology: Open Access
Review Article
Volume 4 Issue 6 - 2016
Upper Gastrointestinal Bleeding in Oncological Patients
Luiz Ronaldo Alberti*, Rodrigo Silveira Santos, Alexandre Fonseca De Castro, Ana Paula De Freitas Porto Fonseca, Eduardo Key, Clarissa Santos Neto, Diego Paim Carvalho Garcia and Andy Petroianu
Department of Surgery, Federal University of Minas Gerais, Brazil
Received: April 21, 2016 | Published: June 20, 2016
*Corresponding author: Luiz Ronaldo Alberti, Adjunct Professor, Department of Surgery, Faculty Researcher at Santa Casa Hospital in Belo Horizonte, UFMG, Gastroenterologist and Endoscopist, Rua do Ouro 1170, apto 1200, CEP 30220-000, Belo Horizonte, Minas Gerais, Brazil, Tel: 55-(31)-99955-0400; Email:
Citation: Alberti LR, Santos RS, Castro AFD, Fonseca APDFP, Key E, et al (2016) Upper Gastrointestinal Bleeding in Oncological Patients. Gastroenterol Hepatol Open Access 4(6): 00123. DOI: 10.15406/ghoa.2016.04.00123

Core Tip

Bleeding is a relatively common phenomenon in patients with solid neoplasms, occurring in up to 10% of all patients in advanced stages of cancer. Therefore, this study aims to discuss clinical support management, endoscopic strategies, radiotherapy, chemotherapy, as well as endovascular and surgical interventions.

Abstract

Bleeding is a relatively common phenomenon in patients with solid neoplasms, occurring in up to 10% of all patients in advanced stages of cancer. The objective of this article is to review the etiology, clinical manifestations, and treatment of acute upper gastrointestinal bleeding in cancer patients, understanding that chronic and occult blood losses are not within the scope of this text. To achieve better outcomes in the management of this entity, a multidisciplinary approach is mandatory. Therefore, this study aims to discuss clinical support management, endoscopic strategies, radiotherapy, chemotherapy, as well as endovascular and surgical interventions.

Keywords: Upper gastrointestinal bleeding; Bleeding; Neoplasms; Endoscopy; Treatment; Critical care

Introduction

Bleeding is a relatively common phenomenon in patients with solid neoplasms, occurring in up to 10% of all patients in advanced stages of cancer [1]. This condition can cause serious morbidity and even death. Upper gastrointestinal bleeding is defined as a bleeding resulting from a site proximal to the Treitz ligament. In an observational prospective study of patients either being admitted to the hospital or during their hospitalization in acute palliative care units, upper sources of bleeding were present in 7% of the cases [2]. In another prospective cohort, bleeding was also present in 5% of the cancer patients in the last three days of their lives [3].

The objective of this article is to review the etiology, clinical manifestations, and treatment of acute upper gastrointestinal bleeding in cancer patients, understanding that chronic and occult blood lossesare not within the scope of this text. To achieve better outcomes in the management of this entity, a multidisciplinary approach is mandatory. Therefore, this study aims to discuss clinical support management, endoscopic strategies, radiotherapy, chemotherapy, as well as endovascular and surgical interventions.

Etiology of Upper Gastrointestinal Bleeding in Patients with Cancer

The main causes of upper gastrointestinal bleeding in patients with cancer is a matter of debate. A prospective study of 65 oncologic patients conduced at the Memorial Sloan-Kettering Cancer Center found that hemorrhagic gastritis was the main cause of bleeding, present in 40% of the patients, followed by benign peptic ulcer disease in 22% of the cases [4]. In the same series, gastric cancer was seen in 28% of the patients, although it was considered the source of bleeding in only 15%.

Many authors argue that the etiology of upper gastrointestinal bleeding in oncological patients is the same as in the general population, with peptic ulcersmost commonly caused by acute blood loss, esophageal and gastric varices, and esophagitis and erosive lesions [5]. In this context, acute bleeding stemming directly from the tumor itself would be a less common event (2.9% to 4% of all cases), since these patients commonly present chronic blood loss [6]. Chemotherapy, nonsteroidal anti-inflammatory drugs, and anticoagulants are potential agents that can contribute to erosive lesions and bleeding in cancer patients. In patients with cirrhosis, one population based study also claims that variceal bleeding corresponds to a significant proportion of the cases (50%-60%) [7]. Cancer patients can also present portal hypertension and esophageal or gastric varices caused by diffuse liver infiltration, portal vein thrombosis, or hepatic vein thrombosis (Budd-Chiari syndrome). In many cases, they exhibit a state of hypercoagulability that is predisposed to thrombosis. Thus, portal hypertension with varices must be included in the potential sources of bleeding in oncological patients even if they do not present cirrhosis or diffuse liver infiltration [8].

One large retrospective database study of 240,428 endoscopies performed in a wide range of clinics to search for the cause of upper gastrointestinal bleeding (variceal bleeding was excluded from the analysis) revealed that peptic ulcers were present in 32.7% of the patients, followed by erosion in 18.8% of the cases [9]. Among the patients with ulcers, gastric ulcers were more common than duodenal ulcers (54.4% and 37.1%, respectively). Table 1 presents the main causes of upper gastrointestinal bleeding diagnosed through endoscopic examination [10,11].

Peptic ulcer disease

Esophageal and gastric varices

Hemorrhagic gastritis

Esophagitis

Duodenitis

Mallory-Weiss tears

Angiodysplasia

UGI malignancy

Anastomotic ulcers

Dieulafoy (abnormally large tortuous submucosal artery) lesions

Table 1: Major causes of upper gastrointestinal bleeding [10,11].

In contrast to these data, other authors advocate that tumorsare the most common cause of upper gastrointestinal bleeding in cancer patients, since it can directly bleed from lesions of the gastrointestinal tract, including esophageal cancer, gastric cancer, gastric lymphoma, gastrointestinal stromal tumors, and metastatic tumors involving the stomach. A retrospective review of patients referred to an endoscopy unit in a reference cancer center in Brazil found that tumorswere the most common cause of bleeding (23.8%), followed by varices (19.7%), peptic ulcer (16.3%), gastroduodenal erosions (10.9%), angioectasia (7.5%), undefined (6.8%), metastasis (4.1%), esophageal mucosal injury (4.1%), hypertensive gastropathy (2.0%), Mallory-Weiss tear (1.4%), and others (3.4%) [12]. In the same study, consideringonly the patients with luminal tumors in the upper gastrointestinal tract (oropharynx, hypopharynx, esophagus, stomach and gastric stump), the main causes of bleeding were tumors (84.4%), ulcers (6.3%), undefined (6.3%), and varices (3.1%). Among patients with tumors located outside the gastrointestinal tract, the causes of bleeding were similar to those found in the general population (ulcer, gastroduodenal erosions, and varices); nevertheless, metastases were the source of bleeding in a significant number of patients (11%). Although these findings are from one reference center and, for better reliability, the data needs to be reproduced in other studies, these results show that tumor bleeding may well play a major role in the source of acute blood loss, especially in patients with upper gastrointestinal tract cancer.

Clinical Presentation

Clinical history

The medical history, physical exam, and initial laboratory exams are important in the evaluation of recommendations for volemic resuscitation (crystalloids or hemoderivates), endoscopy, and surgery. The initial evaluation must be objective, in search of a diagnosis, so as not to delay the beginning of resuscitation procedures, and a complete medical history must be obtained after the patient has been stabilized.

Past episodes of gastrointestinal bleeding and its causes should be studied, giventhat up to 60% of the cases of upper gastrointestinal bleeding result from a gastrointestinal lesion with prior bleeding, the use of non-steriodal anti-inflammatory drugs (NSAID) or aspirin, anticoagulants, and antiplatelets [13]. Involuntary weight loss, dysphagia, smoking, and alcoholism suggest malignity, especially within the gastrointestinal tract. Patient medical history provides the path to the cause of upper gastrointestinal bleeding, as summarized in Table 2 [11].

Etiology of the Bleeding

Data from Clinical History

Mallory-Weiss lesion

Alcoholism/hyperemesis prior to hematemesis

Esophageal ulcer

Odynophagia, Gastroesophageal Refluz Disease (GERD), intake of esophageal-toxic medication

Peptic ulcer

Epigastric pain or in hepatitis D virus (HDV), NSAID

Acute gastric mucosal lesions

Patients in intensive care, active acute gastrointestinal bleeding after hospitalization, respiratory insufficiency, or a combination of these

Vericose veins, hypertensive gastropathy

Alcoholism, Cirrhosis

Gastric antral vascular ectasia

Cirrhosis, renal insufficiency

Malignity

Recent weight loss, dysphagia, cachexia, early satiety

Angiodysplasia

Renal insufficiency, hereditary hemorrhagic telangiectasia

Aortoenteric fistula

Known or already operatedaortic aneurysm

Table 2: Data obtained through clinical history regarding the cause of gastrointestinal bleeding.

The presentation and appearance of blood helps to locate the bleeding and evaluate its severity. Melena is known as black feces with a bad odor. The cases of excessive upper gastrointestinal bleeding appear with melena in nearly 75% of the cases and with hematemesis in approximately 50% [14]. Hematemesis indicates bleeding proximal to the Treitz ligament and suggests a greater volume of bleeding when compared to patients that present a dark colored vomit. Approximately 90% of the cases of melena result from upper gastrointestinal bleeding due to the degradation of the blood during gastrointestinal passage and only 10% are secondary to lower gastrointestinal bleeding (hemorrhaging distal to the Treitz ligamento) [11]. Hematochezia can occur in upper gastrointestinal bleeding, and should be eliminated, when accompanied by signs of hypovolemia or hypoperfusion.

Physical exam

The physical exam should be performed with emphasis on the evaluation of the hemodynamic repercussion, abdominal exam (search for complications, such as: signs of peritoneal irritation), stigmas of portal hypertension (jaundice, vascular spiders, palmar erythema, hepatomegaly, ascites, and caput medusa), and rectal examination. The severity of blood loss is estimated by the hemodynamic state and alterations in target organs (Table 3) [11].

Severity of Bleeding

Physical Signs/ Degree of Volemic Loss

Average

Moderate

Severe

Volemic Loss

<1L

1-2L

>2L

Arterial Loss

Normal

Normal –Slightly below the lower limit

Hypotensive

Orthostatic Hypotension

No

Possible

Common

Tachycardia

>100

>120

>140

Skin

Hot, well perfused

Cutaneous pallor

Cold and sudoretic

Respiratory Rate

20-30

30-35

>35

Urinary Output (Ml/H)

20-30

15-May

Negligible

Mental State

Moderately anxious

Anxious, confused

Confused, lethargic

Table 3: Correlation between the physical signs and the severity of upper gastrointestinal bleeding.

As regards the abdominal exam, increased hydroaerial noises (HAN) are consistent with upper gastrointestinal bleeding, since blood in the proximal intestine is an irritation that stimulates peristaltic movements, while normal HAN are more consistent with lower gastrointestinal bleeding. Diminished HAN suggest intestinal ischemia, paralytic ileum, or late mechanical obstruction. Abdominal pain is uncommon in the cases of uncomplicated upper gastrointestinal bleeding. Intense abdominal pain suggests gastrointestinal bleeding associated with mesenteric ischemia, intestinal obstruction, or gastrointestinal perforation [11]. Peritoneal irritation or involuntary defense demands the exclusion of gastrointestinal perforation before performing the upper gastrointestinal endoscopy (UGE). A careful rectal exam should be performed, incluDing the determination of the type of bleeding (hematochezia or melena), as well as the inspection of external hemorrhoids and anal fissures.

Laboratory exams

The reduction of hemoglobina reflects the degree of blood loss after 24 hours or more of acute bleeding, given that, initially, there is a proportional loss of plasma and red blood cells. Later, the reduction of hemoglobin occurs due to the migration of extravascular liquid, with this dilution increased by venous hydration. The erythrogram in series is used to evaluate the severity of upper intestinal bleeding, but it must be associated with the hemodynamic evaluation, since hyperhydration can falsely diminish to hemoglobin. Central venous pressure, or Swann-Ganz catheter, aid in the volemic resuscitation of patients with comorbidities in which the intravascular volume is difficult to evaluate clinically [15,16], such as in patients with cardiac or renal insufficiency. Additional laboratory exams include the coagulogram, electrolyte, arterial gasometry, urea, creatinine, and hepatic enzymes.

The application of a basic electrocardiogram in the first stage of medical care is useful, since bleeding and hypovolemia can precipitate myocardial ischemic events [17]. With the elderly patient who remains with hypotension and tachycardia, despite the adequate volume replacement, one should contemplate the possibility of an acute myocardial infaction. The initial X-ray of the thorax is also useful in the case of an unfavorable evolution associated with pulmonary aspiration.

Nasogastric catheter

The passage of a nosagastric catheter and gastric irrigation with saline solution is beneficial to detect the presence, aspect, and volume of blood, to clean the field for endoscopic visualization, and to prevent the aspiration of gastric contents. An aspiration with a large quantity of blood, eliminated through a traumatic endotracheal intubation, can confirm upper gastrointestinal bleeding. The bright red blood suggests active bleeding, while the dark red blood suggests recent bleeding. The continuous aspiration of bright red blood suggests severe active bleeding, associated with a higher rate of evidence of active bleeding and other endoscopic stigmas of recent hemorrhaging while performing an emergency UGE, as compared to a dark red aspiration or without the presence of blood [18].

An aspiration without blood does not exclude the possibility of recent gastric bleeding that ceased a few hours earlier, due to the previous gastric emptying or duodenal bleeding, whose content did not flow back through the pylorous [19]. One bilious aspiration, without blood, practically excludes this alternative; however, it does suggest that the bleeding is distal to the Treitz ligament or that it had ceased many hours earlier. The introduction of the nasogastric catheter is uncomfortable but rarely causes complications. The main complications include nosebleeds, due to the traumatic passage of the tube, and gastric erosions, due to the aspiration of the catheter. The erosions are recognized as being multiple, collinear, equidistant, rounded, and relatively uniform, as well as being in the same stage of evolution [11]. In a review of 152 nasogastric catheterisms in patients with upper gastrointestinal bleeding, considering that of these, 125 had suffered an acute myocardial infarction within a period of 30 days prior to the procedure, only two (1.3%) cases presented clinically significant complications, including one case of nosebleeds and another of gastric erosion induced by the tube, both of which were treated with a blood transfusion (red blood cell concentrates), evolving with no clinical sequelae [18]. The risk of nosebleeds is reduced with the use of a correct technique, when introduced softly, with lubrification of the end of the tube, with cooperation from the patient, suspension of venous heparine therapy four hours prior to the introduction of the catheter, and avoiding the insertion when a coagulopathy is detected. The risk of introducing gastric erosions is diminished when suction is applied in the nasogastic probe in a intermittent manner, using low-pressure negative aspiration and the early removal of the tube after the bleeding has ceased through the use of flexible probes with multiple orifices.

Risk stratification

Approximately 80% of the bleeding of the upper gastrointestinal tract ceases spontaneously, without recurrence. Morbidity and mortality occur in the remaining 20%, with persistent and recurrent bleeding. The stratificiation of the patients in low and high risk categories for rebleeding and mortality is an essential step toward the drafting of therapeutic proposals [20,21]. To achieve this, scales (scores) were drafted from the clinical, laboratory, and endoscopic criteria. The prognostic predictors most commonly used in the evaluation of patients with upper gastrointestinal bleeding are: a) The Blatchford Score [22] (Table 4), consisting of only clinical and laboratory parameters, is proposed to predict the need for treatment (blood transfusion, endoscopic hemostasis, or surgical intervention) in patients with upper gastrointestinal bleeding even before performing the UGE. This score also makes it possible to perform the triage of those patients that require an emergency high gastrointestinal endoscopy (in the first 24 hours).

Admission Parameters

Score

Urea (Mg/Dl)

>6.5<8.0

2

>8.0<10.0

3

>10.0<25.0

4

>25.0

6

Hemoglobin (G/Dl)

Man

>12.0<13.0

1

>10.0<12.0

3

<10.0

6

Woman

>10.0<12.0

1

<10.0

6

Systolic Blood Pressure (mmHg)

100 to 109

1

90 to 99

2

< 90

3

Other Parameters

Pulse> 100 Bpm

1

Melena as the 1st Symptom

1

Syncope

2

Hepatopathy

2

Cardiac Insufficiency

2

Table 4: Blatchford Score.
*A score of above zero can be indicative of the need for treatment (blood transfusion, endoscopic hemostasis, or surgical intervention).

b) Rockall et al. [23], based on a study involving 5,810 patients, drafted a standardized score for the evaluation of factors that predict the mortality and risk of rebleeding in patients with upper gastrointestinal bleeding (Table 5). The risk factors observed were age, the presence of a state of shock, existence of comorbidities, endoscopic diagnosis, and endoscopic stigmas of recent bleeding. According to this study, 41.1% of the patients who had 08 (eight) or more points in this score died due to upper gastrointestinal bleeding, and 53.1% presented rebleeding. By contrast, among those patients that presented a score of less than or equal to 2, less than 1% of the cases died and less than 6% presented rebleeding.

Score

0

1

2

3

Age

<60a

60 a 79a

>80a

State of Shock

Pulse<100                       Sist BP>100

Pulse>100               Sist BP<100

Pulse>100                 Sist BP<100

Comorbidities

Absent

Circulatory or coronary insufficiency

Renal or hepatic insufficiency or disseminated malignant disease

Endoscopic Signs of Bleeding

None/flat and dark coagulation

Raised, bright blood clot or visible blood vessel

Diagnosis

Mallory Weiss syndrome/absence of other diagnosis

All other diagnoses

Malignant disease of the upper gastrointestinal tract

Table 5: Rockall Score.

The use of a risk stratification score has the objective of providing the emergency ward doctor with criteria for the proper triage of patients according to the severity of their medical condition. The Rockall or Blatchford scores are especially useful to define those patients with a low risk of morbi-mortality, who can be released from the hospital earlier, without the need for intensive therapy and without the need for emergency UGE in the first 24 hours. The use of these scores is therefore recommended as a basis for risk stratification in these urgency and emergency units. A score of above 02 can be indicative of patients at risk of rebleeding or death.

Initial approach

The initial stabilization must include the evaluation of the airways, respiration and circulation, venous access, and the collection of laboratory exams, in addition to, when indicated, the administration of fluids, blood transfusion, cardiorespiratory support, and treatment of severe concomitant diseases, such as sepsis or acute myocardial infactions. In patients that present respiratory insufficiency or hemodynamic instability, the UGE should be delayed until the patient is adequately resuscitated and stabilized.

General support measures

Generally, patients receive supplementary oxygen by nasal catheter to compensate for the loss of the carrier capacity of oxygen, due to the loss of red blood cells. In the presence of massive bleeding, persistent hematemesis, hypoxia, tachypnea, or alteration of one’s mental state, an immediate and definitive airway must be evaluated (example: endotracheal intubation) to protect the aspiration airways and supplementary oxygenation [24]. Non-invasive monitoring with oximetry, non-invasive measuring of blood pressure, and continuous ECG are recommended. In patients with hemodynamic instability, it may be necessary to apply an invasive monitoring with central venous pressure (CVP), intra-arterial pressure (IAP), or Swan-Ganz catheter. A vesical probe with a Foley catheter is indicated in patients in a state of shock, or in those that present massive bleeding, in order to control urinary output [25].

Fluid Therapy

Patients are evaluated to determine the severity of bleeding (Table 3) and define the requirements for crystalloid infusion (saline solution or lactated ringer’s solution) or a blood transfursion (red blood cell concentrates, fresh frozen plasma, or platelets), which should be properly washed due to the presence of concomitant diseases, especially cardiovascular disease and renal insufficiency. Intravenous access is guaranteed by two thick caliber peripheral venous catheters. Thepatients with active bleeding can require around two to three liters of crystalloid solution to maintain the blood pressure, and if this does not produce a response to the initial rapid blood infusion, the transfusion of a specific type of blood may be necessary.

Blood Transfusion

The transfusion of red blood cell concentrates serves to improve the oxygenation of the tissues and impede damage to the target organs. The need for blood transfusions is individual, with no level of hemoglobin presenting an absolute indication, with the requirements determined by various factors, including age, presence of comorbidities, cardiovascular state, basal hemoglobin, and volume of blood, together with the current level of hemoglobin. Red blood cell concentrates should be transfused in patients who present an excessive blood loss, who present persistent active bleeding, and who present signs of cardiac, renal, or cerebral hypoperfusion [5,11]. Patients who present hemodynamic instability associated with active bleeding or recent engina are recommended for early blood transfusion. Patients with vericose upper gastrointestinal bleeding should be treated conservatively, transfused with a hemoglobin rate of less than 7.0 g/dl to avoid a worsening of bleeding caused by an increase in rebound portal hypertension [11].

Young and healthy patients who do not present uncompensated comorbidities more adequately toleratehemoglobin rates of 7.0 g/dl, while the elderly, as well as cardiopathy and chronic renal patients, have a lower cardiopulmonary reserve and are unable to tolerate hemoglobin of less than 10 g/dl [20]. The coagulopathy can exacerbate the bleeding and should be treated with a transfusion of fresh frozen plasma or platelets, on a case by case basis. One useful piece of advice is to transfuse 01 unit of fresh frozen plasma for each 04 units of red blood cell concentrate in order to substitute the coagulation factors that have been lost [25]. The international normalized ratio (INR) of less than 1.5 does not require treatment. Discrete thrombocytopenia (50,000 - 90,000 platelets/ml) rarely contributes to upper gastrointestinal bleeding, whereas a count of less than 50,000/ml in the presence of active bleeding can require a transfusion of platelets. This general rule is individualized according to multiple factors, including the severity of bleeding, the presence of other coagulopathies, and an altered platelet function, such as those induced by NSAID [26]. When surgery is deemed necessary, the coagulopathies should be corrected before beginning the procedure.

Blood transfusions rarely have collateral effects; however, if they occur, they can be severe. Despite the triage performed with blood donors, the HIV virus, type 1 and type 2 HTLV (Human T-cell Lymphotropic Virus), hepatitis B, hepatitis C, and parvovirosis, though rare, can be transmitted through blood transfusions. In addition to bacterial infections, particularly the Yersinia enterocolitica in the transfusion of red blood cell concentrates and Staphylococcus aureus in the transfusion of platelets [26]. A rapid transfusion can induce congestive heart failure and pulmonary edema in patients that have suffered prior congestive heart failure or other heart diseases and should therefore be transfused carefully and slowly. Diuretics can be administered both before and during the procedure in these patients.

Therapeutics of Upper Gastronintestinal Bleeding

Clinical treatment

The use of proton-pump inhibitors (PPIs), in cases of upper gastrointestinal bleeding caused by peptic ulcers, significantly reduces the rates of rebleeding, the need for surgical intervention, and the need for endoscopic retreatment, when compared to the placebo or H2 blockers [20,21]. In addition, reductions in the mortality rates may well result from the use of PPIs in high-risk patients (active bleeding or non-bleeding visible blood vessels upon application of UGE) [27]. The venous formulations of PPIs can be administered in bolus or by prolonged infusion and, in the eventual lack of these formulations; the use of doubled oral doses of PPIs (every 12 hours) presents satisfactory results. In patients that, when undergoing an endoscopy, do not present active bleeding, ulcers with visible blood vessels or adhered coagulation (i.e., low risk for rebleeding), the treatment can be started with the oral administration of PPIs. It is suggested that omeprazole be used at a dose of 80 mg, intravenously, in bolus, followed by an infusion of 8 mg/h, for 72 hours, at which time it should be exchanged for 20 mg, administered orally (once per day) for eight weeks [5,27]. The suspension of the medication after this period will depend on the correction of the percipient factors, such as H. pylori, NSAIDs, and acetylsalicylic acid (ASA).

The use of other drugs, such as somatostatin or octreotide, can be beneficial due to the effects produced in the reduction of splanchnic blood flow, the inhibition of acid secretion, and the supposed gastric cytoprotective action [27]. However, due to the high cost and low availability, the use of these drugs is reserved for rare occasions in which the conventional therapy has proven to be inefficient.

Endoscopic therapy

Over the last decade, many randomized clinical studies, as well as meta-analyses, demonstrated that endoscopic therapy reduces the indices of the recurrence of gastrointestinal bleeding, the need for emergency surgery, and mortality in patients with peptic ulcers with active bleeding or with visible blood vessels [20,21,27]. The endoscopic therapy, in the majority of case series, demonstrates a success rate of more than 94% in cases following the initial approach to bleeding lesions. However, the inidices of recurrent bleeding are significant (15-20%), particularly in patients with large and deep ulcers, coagulopathies, conditions of severe comorbidity, hypertension, or bleeding that develops during hospitalization. These are frequently elderly patients with a high risk of surgical mortality and with indices of post-operative mortality of 15% to 25%. One prospective study, carried out with 92 patients with an average age of 65 years who had presented rebleeding after endoscopic control, demonstrated that endoscopic re-treatment reduces the need for surgery, wihout increasing the risk of death and with less complications than surgery [20,28]. In patients with persistent hypotension, in which the hemostasis was not successful, repeated and failed endoscopic procedures can negatively affect survival rates. In some studies, early elective surgery, after the endoscopic control of bleeding in high-risk patients, has been reported to be a successful measure to reduce recurrent bleeding, morbidity, and mortality27. However, this strategy is not universally accepted and requires further study. The combination of the injection of an epinephrine solution and thermal therapies are considered the best approach to control continuous bleeding or prevent rebleeding in visible blood bessels of ulcered lesions.

Currently, in bleeding esophageal varices, the elastic ligature has been preferred as the therapeutic modality. This procedure reduces the risk of rebleeding and appears to improve survival rates. Its efficacy in the short term of schlerotherapy is less than that of elastic ligature. Schlerotherapy is associated with the highest indices of complication, such as perforation and rebleeding. By contrast, the late rebleeding after the elimination of varices though shlerotherpay appear to be less than those from elastic ligature [27,29]. Enscopic interventions can be used for the treatment of upper gastrointestinal bleeding related to neoplasias of the gastrointestinal tract. Akhtar et al. [30] reported, in a series of 48 consecutive patients with cancer of the esophagogastric junction who were submitted to an endoscopy with coagulation in an argon plasma beam, bleeding was well-controlled in three of the five patients with acute upper gastrointestinal bleeding. However, in patients with excessive bleeding secondary to advanced malignant gastroduodenal neoplasms, endoscopic therapy appears to provide a limited benefit. Loftus et al. [31] in a study carried out with 1,083 consecutive patients with upper gastrointestinal bleeding, observed that in 21 patients (1.9%) advanced tumors were detected in the stomach and duodeno, of which 15 received endoscopic therapy, with 11 gastric and 4 duodenal. The endoscopic treatment consisted of an injection of adreline, electrocoagulation, heater probes, argon plasma, sodium tetradecyl sulfate, and laser therapy. The initial endoscopy reached hemostasis in 10 to 15 patients (67%); however, recurrence of bleeding was observed in 8 to 10 (80%), and in all of the 5 in which endoscopic hemostasis was not achieved, bleeding persisted. Five severe complications related to the procedure occurred, of which two were fatal.

Interventional Radiology - The Role of Angiography

Upper gastrointestinal bleeding may sometimes be the immediate cause of death in patients with advanced cancer. Bleeding can result from local blood vessel damage and invasion or from systemic processes (liver failure, radiotherapy, chemotherapy, disseminated intravascular coagulopathy, among others) [1]. Although most cases of upper gastrointestinal bleeding cease on their own or are controlled endoscopically, some cases appear in which the source of bleeding can not be indentified or treated endoscopically. If bleeding is heavy (>1.0 ml/min) angiography can be used both to aid in diagnosing the location of the bleeding and to provide angiographic intervention to control the bleeding source. Endoscopy represents a fast, safe, and a minimally invasive option to surgery in selective cases. Because ongoing bleeding typically coincides with the clinical deterioration of the oncological patient, embolization should be performed early in patients with upper gastrointestinal bleeding who have not been treated endoscopically.

Agents used for embolization

Selective embolization of the bleeding artery can be performed with a variety of agents that mechanically occlude the vascular supply of the bleeding lesion (coils, PVA, gelatin sponge), infusion of vascoconstricting agents to decrease the blood flow to the bleeding site, or by a combination of these techniques [2]. The agents are either temporary or permanent [32] (Table 6).

Agents

Permanent

Temporary

- Coils

- Absorbable Gelatin Sponge (Gelfoan)

- Glue

- Vasopressin*

- Particles (Pva)

- Ethylenevinyl Alcohol Copolymer

- N-Butyl2cyanoacrylate (Nbca)

Table 6: Materials used for embolization.
* Vasoconstricting agent.

Advantages of using gelatin sponges include cost effectiveness, widespread availability, and temporary occlusion. These sponges are more commonly used in combination with coils and particles when bleeding occurs from a lesion that is not expected to heal spontaneously, such as tumors [33]. Coils and microcoils have become the preferred agent for embolizing upper gastrointestinal bleeding by most interventionalists. These can be deployed selectively by means of a microcatheter into the distal bleeding artery, thus preserving the collateral blood supply to other tissues. Vasopressin causes generalized vasoconstriction in vessel walls (arterioles, capillaries, and venules), in turn producing a rapid reduction in the local blood flow which allows for a stable clot formation at the bleeding site. This should be used cautiously in patients with severe hypertension, coronary artery disease, peripheral artery disease, arrhythmias, and congestive heart failure. Rebleeding is common once the vasopressin has been stopped, and its use becomes much less frequent after the introduction of microcatheters and microcoils [34].

Technique

Transcutaneous arterial embolization may be useful in selected patients with cancer and upper gastrointestinal bleeding. This procedure is often performed through a femoral approach, but it can also be performed through a brachial or radial approach. It is generally well tolerated under local anesthesia and mild sUGEtion [35]. Transcatheter interventions include selective embolization of the feeding artery (usually the gastroduodenal artery or left gastric artery), “sandwich” coil occlusion of the gastroduodenal artery (coils and sponge), and empiric embolization of the supposed bleeding vessel. In the last case, the placement of clips at the bleeding site during endoscopy helps the interventional procedure.36 Embolization works by decreasing the blood flow enough to achieve hemostasis while maintaining collateral perfusion in other tissues adjacent to the bleeding site. The procedure begins with the selective catheterization of the celiac artery or the superior mesenteric artery, and contrast extravasation into the bowel lumen is considered definitive evidence of a bleeding site. Sometimes there is only indirect evidence of bleeding in an angiography (early draining vessels, neovascularity, arteriovenous fistulas, and the filling of spaces outside the bowel). Treatment with empiric embolization can be performed in these cases (embolization of a vessel thought to be supplying the bleeding source without bleeding having been demonstrated in the angiography).Empiric embolization is as effective as in those patients who show contrast extravasation during angiography [36].

Embolization of upper gastrointestinal bleeding in oncological patients is commonly performed with a combination of agents: gelatin sponge (Gelfoan), coils, microcoils, and particles. These embolic agents function similarly to surgical ligation by decreasing perfusion pressure to the bleeding site; the reduction of blood flow promotes clot formation. Due to the dual blood supply of the stomach and duodenum, the risk of bowel ischemia is minimal when embolization is performed with coils and absorbable gelatin sponges. The catheter or microcatheter should be inserted into the selected artery in order to avoid deployment of embolic materials in undesired areas. This technique prevents ischemia or infarction, common complications of the procedure (Figures 1 & 2).

Figure 1: Embolization of the gastroduodenal artery in a patient with upper gastrointestinal bleeding. Common hepatic arteriogram shows a focus of extravasation in the region of the duodenum (arrow).
Figure 2: Common hepatic arteriogram after embolization with coils and gelatin sponge shows occlusion of the gastroduodenal artery.

It is imperative to occlude the gastroduodenal artery proximal and distal to the bleeding site. If only the proximal portion of the gastroduodenal artery is occluded, bleeding may persist through the pancreaticoduodenal arcade supplied by the superior mesenteric artery (collateral bleeding through the “back door”). Occasionally, it may be necessary to embolize these arteries in a superselective manner through the superior mesenteric artery using coaxial microcatheters. Embolization is usually most effective when performed in combination with medical therapy to correct the underlying etiology of bleeding. If the patient is unable to form a clot, embolotherapy is likely to fail due to the abundant collateral arterial supply to the stomach and duodenum.

Complications

Embolization is restricted to areas where the blood vessels are accessible by the catheter and where embolization of the blood vessel does not result in the ischemia of key organs [37]. In a review that included patients undergoing embolization for upper gastrointestinal bleeding, complications occurred in 5% to 9% of the patients (bowel ischemia and infarction accounted for the majority of complications) [38] (Table 7).

Complications

- Bowel Infarction

- Groin Hematoma*

- Pseudoaneurysm*

- Dissection*

- Embolism*

- Thrombosis*

- Renal Failure*

Table 7: The complications of embolization.

*Complications associated with arteriography itself.

Efficacy of embolization

Rebleeding is common with intra-arterial vasopressin (9-56% depending upon the bleeding site) and less common with other embolization agents [39,40]. Efficacy of embolization to control upper gastrointestinal bleeding in oncological patients ranges from 60-75% and varies with the type of lesion [41]. If embolotheraphy is unsuccessful, even after more than one procedure, then open surgery may be an alternative to treat these patients (Table 8).

Clinical Failure

- Corticosteroid use

- Anticoagulant use

- Coagulopathy

- Multiorgan failure

- Previous surgery

- Embolization with coils alone

- Longer Time for angiography

Table 8: Factors associated with failed embolization [42].

Surgery

Despite The advances in endoscopic and phramacological therapies, 10% to 15% of the patients presented rebleeding, with the mortality rates in these cases being four to five times greater [43]. The recommendations of surgical treatment for upper gastrointestinal bleeding are summarized in Table 9. The type of surgical treatment depends on the cause of the upper gastrointestinal bleeding, hemodynamic repercussion, comorbidities, complications (perforation), availability of material, and technical knowledge (minimally invasive approach). Czymek et al. [44], in a study carried out with 91 patients (58 men, 33 women) who had been admitted between 2000 and 2009 at the College of Medicine of the University of Luebeck (Germany) and who had undergone surgical treatment due to upper gastrointestinal bleeding, the causes of bleeding included duodenal ulcers in 57 patients (62.6%), gastric ulcers in 25 (27.5%), gastric and duodenal ulvers in 7 (7.7%), and malignant neoplasms in 2 (2.2%). The surgical treatment consisted of ulceroraphy (52.7%), partial gastrectomy with Billroth II reconstruction (31.9%), partial gastrectomy with Billroth I reconstruction (4.4%), gastric wedge resection (4.4%), and total gastrectomy (3.3%). Jairath et al. [32], in a natonal auditing in the United Kingdom, carried out with 4,478 patients in 212 institutions, 97 patients underwent surgical treatment. The surgical procedure performed included ulceroraphy (69%), ulcer excision (3%), ulcer excision with vagatomy/pyeloplasty (2%), partial gastrectomy (9%), and others (16%). The recommendations for surgery were uncontrollable bleeding (82.5%), peritonitis/perforation (6.8%), malignity (4.9%), and others (8.7%). Patients with cancer can benefit from early surgical procedures to control bleeding, especially if endoscopic treatment is not possible. Despite the improvement in the mortality rates with surgery, curative ressecton is relatively uncommon and post-operative complications are common [5].

- Hemodynamic instability after vigorous treatment (>06 units of transfusion)

- Failure of endoscopic treatment

- Recurrence of bleeding after two attempts of endoscopic treatment

- State of shock associated with recurring bleeding

- Continous bleeding with the need for the transfusion of 03 units/day

Table 9: Indication of surgery in acute upper gastrointestinal bleeding.

Radiotherapy

The main causes of upper gastrointestinal bleeding are similar between the oncologic patients and the population in gereral. The minority of theseare due to tumor bleeding, and the aplication of radiotherapy is restricted to these cases [45]. Acute tumor bleeding typically represents a late stage of disease when the neoplasm outgrows its blood supply and causes mucosal ulceration. Virtually any tumor type may bleed. Patients with severe bleeding resulting from malignant upper gastrointestinal tumors show a poor prognosis, the majority of whom die within 12 months [46]. Radiotherapy in these cases is most often palliative. The radiotherapy treatment approach depends on the performance status scale, the previous treatment submitted by the patient, his or her hemodynamic stability, among other factors. In the patients scheduled receive radiotherapy, it is important to monitor hemoglobin levels, asit is known that the presence or absence of molecular oxygen dramatically influences the biological effect of X-rays. A review of relevant clinical data suggests that a maximum oxygenation status in solid tumors is to be expected within the range of 12 g/dl < cHb < 14 g/dl for women and 13 g/dl < cHb < 15 g/dl for men; however, these values are dificult to achieve in patients with upper gastrointestinal bleeding [47]. To produce this effect, molecular oxygen must be present during the radiation exposure or at least during the lifetime of the free radicals generated by the radiation. Oxygen makes the damage produced by free radicals permanent, and hypoxia may play an important role in malignant progression [48]. The esophageal, gastric, and hepatic tumours are examples of tumors that can be treated with radiotherapy in these situations.

Bleeding gastric cancer responses to radiotherapy are not as immediate as with palliative surgery [49]. External beam radiation therapy plays a well-defined role in the control of bleeding in patients with localized but unresectable tumors [50-55]. Palliative doses ranging from 8 Gy per single fraction to 40 Gy in 16 fractions can control the bleeding in approximately 80% of all patients [55]. Treatment is well tolerated with low toxicity and can last the duration of most patients’ lives. There was no difference in response between low and high biologically effective dose regimes. Chemoradiotherapy have also demonstrated a durable effect [49]. Bleeding from hepatic tumors directly invading the gastrointestinal tract is uncommon but should be considered. The treatment of choice against the direct invasion of the gastrointestinal tract by hepatic tumors is palliative surgical resection; however, few patients can receive this procedure due toits poor performance status. Palliative radiotherapy may offer an alternative choice if the patient is not a candidate for surgical ressection. The bleeding can be stopped by doses such as 50 Gy. Doses similar to these are apparently well tolerated by patients who present no liver cirrhosis and by those who had Child’s class A liver cirrhosis [56].

Esophageal cancer may also bleed. External beam radiotherapy with concurrent chemotherapy is a standard approach for patients with locally advanced unresectable or inoperable thoracic and abdominal esophageal cancer who are medically able to tolerate chemotherapy. The landmark RTOG 85-01 trial, demonstrated that the addition of concurrent chemotherapy to conventional fractionation radiotherapy provided a significant survival benefit when compared to treatment with radiotherapy alone [57,58]. In this trial, the radiotherapy dose used was 50 Gy in 25 fractions over five weeks. In patients who cannot tolerate chemotherapy, palliation radiotherapy can be performed in hypofractionated schemes. The minority of esophageal cancers arise in the cervical portion of the esophagus, the majority of which are locally advanced at the time of diagnosis and may bleed [59,60]. The treatment of choice in these tumors is radiotherapy combined with concurrent chemotherapy rather than surgery. It is also important to note that bleeding can occur as sequelae of radiotherapy treatment due to radiation induced ulceretion or telangiectasia. Thrombocytopenia is common in patients undergoing chemotherapy together with radiotherapy, which also favors bleeding. Argon plasma coagulation, hyperbaric oxygen therapy, and formalin therapy are treatment choices in these cases [61].

Chemotherapy and Systemic Therapy

In patients with upper gastrointestinal bleeding secondary to direct tumor effect, in addition to clinical support aimed at stabilization, patients frequently receive one therapeutic modality, depending on the situation (endoscopic intervention, radiotherapy, or endovascular device). Treating the primary cause of the bleeding (primary cancer or an invading metastasis) with chemotherapy or other systemic agents (ex. monoclonal antibodies) can also be useful, but it is most commonly performed after inicial stabilization. In patients with bleeding gastric lymphomas, chemotherapy regimens (R-CHOP in diffuse large B-cell lymphomas, for example) can achieve high response rates and contribute to hthe cessation of acute blood loss. Corticosteroids can play a special role in this specific scenario. Each case must be fully individualized, and the best approach should be chosen on a multidiscliplinary basis.

Conclusion

Acute upper gastrointestinal bleeding has a relatively high rate of mortality, despite the advances in diagnoses and treatments. Malignant neoplasms, though the least likely primary cause of gastrointestinal bleeding, and hematologic and anatomic changes related to cancer, hinder its management. Moreover, oncologic treatments can prsent a wide range of consequences that can lead to occult or massive hemorrhaging. The initial approach to gastrointestinal bleeding is similar in patients with or without cancer; nevertheless, special attention should be given to this condition due to the complication factors, which include hematologic and metabolic diseases, as well as structural abnormalities.

Source of Support

Minas Gerais Research Support Foundation (FAPEMIG) and National Council for Scientific and Technological Research (CNPq) for their financial support.

References

  1. Pereira J, Mancini I, Bruera E (2000) The management of bleeding in patients with advanced cancer. In: Portenoy RK & Bruera E (Eds.), Topics in Palliative Care. Volume 4, Oxford University Press, New York, USA, pp. 163-183.
  2. Hui D, Dos Santos R, Reddy S, Nascimento MS, Zhukovsky DS, et al. (2015) Acute symptomatic complications among patients with advanced cancer admitted to acute palliative care units: A prospective observational study. Palliat Med 29(9): 826-833.
  3. Hui D, Dos Santos R, Chisholm G, Bansal S, Souza Crovador C, et al. (2015) Bedside clinical signs associated with impending death in patients with advanced cancer: preliminary findings of a prospective, longitudinal cohort study. Cancer 121(6): 960-967.
  4. Lightdale CJ, Kurtz RC, Sherlock P, Winawer SJ (1974) Aggressive endoscopy in critically ill patients with up- per gastrointestinal bleeding and cancer. Gastrointest Endosc 20(4): 152-153.
  5. Yarris JP, Warden CR (2009) Gastrointestinal bleeding in the cancer patient. Emerg Med Clin N Am 27(3): 363-379.
  6. Jutabha R, Jensen DM (1996) Management of upper gastrointestinal bleeding in the patient with chronic liver disease. Med Clin North Am 80(5): 1035-1068.
  7. Van Leerdam ME (2008) Epidemiology of acute upper gastrointestinal bleeding. Best Pract Res Clin Gastroenterol 22(2): 209-224.
  8. Oliveira CA, Carvalho GDP, Mota VCA (2015) Hemorragia Digestiva Alta. In: Fonseca RP & Levindo COF (Eds.), Urgências oncológicas no pronto Socorro: uma abordagem para o clinico. São Paulo: Atheneu, Brazil, pp. 101-113.
  9. Enestvedt BK, Gralnek IM, Mattek N, Lieberman DA, Eisen G (2008) An evaluation of endoscopic indications and findings related to nonvariceal upper-GI hemorrhage in a large multicenter consortium. Gastrointest Endosc 67(3): 422-429.
  10. Gilbert DA, Silverstein FE, Tedesco FJ, Buenger NK, Persing J (1981) The national ASGE survey on upper gastrointestinal bleeding. III. Endoscopy in upper gastrointestinal bleeding. Gastrointest Endosc 27(2): 94-102.
  11. Cappell MS, Friedel D (2008) Initial management of acute upper gastrointestinal bleeding: from initial evaluation up to gastrointestinal endoscopy. Med Clin North Am 92(3): 491-509.
  12. Maluf FF, Martins BC, de Lima MS, Leonardo DV, Retes FA, et al. (2013) Etiology, endoscopic management and mortality of upper gastrointestinal bleeding in patients with cancer. United European Gastroenterol J 1(1): 60-67.
  13. Mc Guirk TD, Coyle WJ (1996) Upper gastrointestinal tract bleeding. Emerg Med Clin North Am 14(3): 523-545.
  14. Peter DJ, Doughtery JM (1999) Evaluation of the patient with gastrointestinal bleeding: an evidence based approach. Emerg Med Clin North Am 17(1): 239-261.
  15. Sorensen MB, Christiansen LA, Malmstrom J, Bille BNE (1977) Central hemodynamics in acute gastro-intestinal bleeding. Surg Gynecol Obstet 145(5): 685-690.
  16. Kwan V, Norton ID (2007) Endoscopic management of non-variceal upper gastrointestinal haemorrhage. ANZ J Surg 77(4): 222-230.
  17. Cappell MS (1995) A study of the syndrome of simultaneous acute upper gastrointestinal bleeding and myocardial infarction in 36 patients. Am J Gastroenterol 90(9): 1444-1449.
  18. Cappell MS (2005) Safety and efficacy of nasogastric intubation for gastrointestinal bleeding after myocardial infarction: an analysis of 125 patients at two tertiary cardiac referral hospitals. Dig Dis Sci 50(11): 2063-2070.
  19. Witting MD, Magder L, Heins AE, Mattu A, Granja CA, et al. (2004) Usefulness and validity of diagnostic nasogastric tube aspiration in patients without hematemesis. Ann Emerg Med 43(4): 525-532.
  20. Barkun AN, Bardou M, Kuipers EJ, Sung J, Hunt RH, et al. (2010) International consensus recommendations on the management of patients with nonvariceal upper gastrointestinal bleeding. Ann Intern Med 152(2): 101-113.
  21. Souza CDC, Parente JML, Lima MM, Santos OF (2006-2008) Hemorragia Digestiva Alta Não Varicosa. Projeto Diretrizes da Sociedade Brasileira de Endoscopia Digestiva, gestão.
  22. Blatchford O, Murray WR, Blatchford M (2000) A risk score to predict need for treatment for upper-gastrointestinal haemorrhage. Lancet 356(9238): 1318-1321.
  23. Rockall TA, Logan RFA, Devlin HB, Northfield TC (1996) Risk assessment after acute upper gastrointestinal haemorrhage. Gut 38(3): 316-321.
  24. Rudolph SJ, Landsverk BK, Freeman ML (2003) Endotracheal intubation for airway protection during endoscopy for severe upper GI hemorrhage. Gastrointest Endosc 57(1): 58-61.
  25. McIntyre LA, Hebert PC, Fergusson D, Cook DJ, Aziz A, et al. (2007) A survey of Canadian intensivists’ resuscitation practices in early septic shock. Crit Care 11(4): 74.
  26. Maltz GS, Siegel JE, Carson JL (2000) Hematologic management of gastrointestinal bleeding. Gastroenterol Clin North Am 29(1): 169-187.
  27. Lima DCA, Taranto MPL, Alberti LR (2011) Hemorragia Digestiva. In: Freitas EV, Py L, et al. Gorzoni ML - Tratado de Geriatria e Gerontologia. (3rd edn), Guanabara Koogan, Rio de Janeiro, Brazil.
  28. Khuroo MS, Yattoo GN, Javid G, Khan BA, Shah AA, et al. (1997) A Comparison of omeprazole and placebo for bleeding peptic ulcer. N Engl J Med 336(15): 1054-1058.
  29. Bühler LB, Vermeulen B, Mo P (2005) Treatment of gastrointestinal hemorrhage. Abdom Imaging 30(6): 719-726.
  30. Akhtar K, Byrne JP, Bancewicz J, Attwood SE (2000) Argon beam plasma coagulation in the management of cancers of the esophagus and stomach. Surg Endosc 14(12): 1127-1130.
  31. Loftus EV, Alexander GL, Ahlquist DA, Balm RK (1994) Endoscopic treatment of major bleeding from advanced gastroduodenal malignant lesions. Mayo Clin Proc 69(8): 736-740.
  32. Ramaswamy RS, Choi HW, Mouser HC, Narsinh KH, McCammack KC, et al. (2014) Role of interventional radiology in the management of acute gastrointestinal bleeding. World J Radiol 6(4): 82-92.
  33. Schenker MP, Duszak R, Soulen MC, Smith KP, Baum RA, et al. (2001) Upper gastrointestinal hemorrhage and transcatheter embolotherapy: clinical and technical factors impacting success and survival. J Vasc Interv Radiol 12(11): 1263-1271.
  34. Darcy M (2003) Treatment of lower gastrointestinal bleeding: vasopressin infusion versus embolization. J Vasc Interv Radiol 14(5): 535-543.
  35. Broadley KE, Kurowska A, Dick R, Platts A, Tookman A (1995) The role of embolization in palliative care. Palliat Med 9(4): 331-335.
  36. Padia SA, Geisinger MA, Newman JS, Pierce G, Obuchowski NA, et al. (2009) Effectiveness of coil embolization in angiographically detectable verus non-detectable sources of upper gastrointestinal hemorrhage. J Vasc Interv Radiol 20(4): 461-466.
  37. Srivastava DN, Gandhi D, Julka PK, Tandon RK (2000) Gastrointestinal hemorrhage in hepatocellular carcinoma: management with transhepatic arterioembolization. Abdom Imaging 25(4): 380-384.
  38. Mirsadraee S, Tirukonda P, Nicholson A, Everett SM, McPherson SJ (2011) Embolization for non-variceal upper gastrointestinal tract haemorrhage: a systematic review. Clin Radiol 66(6): 500-509.
  39. Loffroy R, Rao P, Ota S, De Lin M, Kwak BK, et al. (2010) Embolization of acute nonvariceal upper gastrointestinal hemorrhage resistant to endoscopic treatment: results and predictors of recurrent bleeding. Cardiovasc Interv Radiol 33(6): 1088-1100.
  40. Ripoll C, Bañares R, Beceiro I, Menchén P, Catalina MV, et al. (2004) Comparison fo transcatheter arterial embolization and surgery for treatment of bleeding peptic ulcer after endoscopy treatment failure. J Vasc Interv Radiol 15(5): 447-450.
  41. Lieberman DA, Keller FS, Katon RM, Rosch J (1984) Arterial embolization for massive upper gastrointestinal tract bleeding in poor surgical candidates. Gastroenterology 86(5): 876-885.
  42. Lundgren JA, Matsushima K, Lynch FC, Frankel H, Cooney RN (2011) Angiographic embolization of nonvariceal upper gastrointestinal bleeding: predictors of clinical failure. J Trauma 70(5): 1208-1212.
  43. Jairath V, Kahan BC, Logan RF, Hearnshaw SA, Dore CJ, et al. (2012) National audit of the use of surgery and radiological embolization after failed endoscopic haemostasis for non-variceal upper gastrointestinal bleeding. Br J Surg 99(12): 1672-1680.
  44. Czymek R, Großmann A, Roblick U, Schmidt A, Fischer F, et al. (2012) Surgical management of acute upper gastrointestinal bleeding:still a major challenge. Hepatogastroenterology 59(115): 768-773.
  45. Mitchell SC, David F (2008) Initial Management of Acute Upper Gastrointestinal Bleeding: From Initial Evaluatio up to Gastrointestinal Endoscopy. Med Clin N Am 92(2008): 491-509.
  46. Savides TJ, Jensen DM, Cohen J, Randall GM, Kovacs TO, et al. (1996) Severe upper gastrointestinal tumor bleeding: endoscopic findings, treatment, and outcome. Endoscopy 28(2): 244-248.
  47. Peter V, Arnulf M, Michael H (2006) Impact of Hemoglobin Levels on Tumor Oxygenation: the Higher, the Better? Strahlenther Onkol 182(2): 63-71.
  48. Eric JH, Amato JG (2011) Radiobiology for the radiologist, 7th edn, Wolters Kluwer, UK, p. 86-103.
  49. Yuan ST, Wang FL, Liu N, Liu YH, Liu SG, et al. (2015) Concurrent involved-field radiotherapy and XELOX versus XELOX chemotherapy alone in gastric cancer patients with postoperative locoregional recurrence. Am J Clin Oncol 38(2): 130-134.
  50. Tey J, Back MF, Shakespeare TP, Mukherjee RK, Lu JJ, et al. (2007) The role of palliative radiation therapy in symptomatic locally advanced gastric cancer. Int J Radiat Oncol Biol Phys 67(2): 385-388.
  51. Harvey JA, Bessell JR, Beller E, Thomas J, Gotley DC, et al. (2004) Chemoradiation therapy is effective for the palliative treatment of malignant dysphagia. Dis Esophagus 17(3): 260-265.
  52. Burmeister BH, Denham JW, O'Brien M, Jamieson GG, Gill PG, et al. (1995) Combined modality therapy for esophageal carcinoma: preliminary results from a large Australasian multicenter study. Int J Radiat Oncol Biol Phys 32(4): 997-1006.
  53. Hashimoto K, Mayahara H, Takashima A, Nakajima TE, Kato K, et al. (2009) Palliative radiation therapy for hemorrhage of unresectable gastric cancer: a single institute experience. J Cancer Res Clin Oncol 135(8): 1117-1123.
  54. Asakura H, Hashimoto T, Harada H, Mizumoto M, Furutani K, et al. (2011) Palliative radiotherapy for bleeding from advanced gastric cancer: is a schedule of 30 Gy in 10 fractions adequate? J Cancer Res Clin Oncol 137(1): 125-130.
  55. Tey J, Choo BA, Leong CN, Loy EY, Wong LC, et al. (2014) Clinical outcome of palliative radiotherapy for locally advanced symptomatic gastric cancer in the modern era. Medicine 93(22): 118.
  56. Hung CH, Yi Shin H, Chen CL, Yee C, Kwan HC, et al. (1998) Radiotherapy in the treatment of duodenal bleeding due to hepatocellular carcinoma invasion. J Gastroenterol Hepatol 13(11): 1143-1145.
  57. Herskovic A, Martz K, al-Sarraf M, Leichman L, Brindle J, et al. (1992) Combined chemotherapy and radiotherapy compared with radiotherapy alone in patients with cancer of the esophagus. N Engl J Med 326(24): 1593-1598.
  58. Al Sarraf M, Martz K, Herskovic A, Leichman L, Brindle JS, et al. (1997) Progress report of combined chemoradiotherapy versus radiotherapy alone in patients with esophageal cancer: an intergroup study. J Clin Oncol 15(1): 277-284.
  59. Mendenhall WM, Sombeck MD, Parsons JT, Kasper ME, Stringer SP, et al. (1994) Management of Cervical Esophageal Carcinoma. Semin Radiat Oncol 4(3): 179-191.
  60. Collin CF, Spiro RH (1995) Carcinoma of the cervical esophagus: changing therapeutic trends. The American Journal of Surgery 148(4): 460-466.
  61.  Jervoise NA, Susan ED, Catherine G, William HA, Edwin S (2011) Practice guidance on the management of acute and chronic gastrointestinal problems arising as a result of treatment for cancer. Gut 61(2): 179-192.
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