Journal of ISSN: 2373-633XJCPCR

Cancer Prevention & Current Research
Volume 5 Issue 4 - 2016
Hypothesis New Highlight on Cancer Prevention Based on Published “an Index of the Fate of Circulating Cancer Cells”
Wilson IB Onuigbo*
Medical Foundation and Clinic, Nigeria
Received: June 04, 2016 | Published: August 29, 2016
*Corresponding author: Wilson IB Onuigbo, Medical Foundation & Clinic, 8 Nsukka Lane, Enugu 400001, Nigeria. Email:
Citation: Onuigbo WIB (2016) Hypothesis New Highlight on Cancer Prevention Based on Published “an Index of the Fate of Circulating Cancer Cells”. J Cancer Prev Curr Res 5(4): 00168. DOI: 10.15406/jcpcr.2016.05.00168


The Lancet in 1963 published my hypothesis entitled “AN INDEX OF THE FATE OF CIRCULATING CANCER CELLS [1].” Since then, there has been another development based on the strict observation of necrosis occurring among lung cancer cells when they are commingled with red cells in the thoracic duct [2]. Indeed, the next step was to name, as “Erythrocyte Associated Necrosis Factor” (EANF), the natural explanatory element involved [3].

Thereafter, in a series [4-10], it was repeatedly demonstrated that this Factor is at work in explaining some anomalies detected in the colonization patters of lung cancer. On this account, what of the anomaly of glomerular deposits being relatively rare in lung cancer?

For instance, Willis [11] was struck by the common feature of normal glomeruli standing out unscathed among parenchymatous metastases in the kidney? Figure 1 of my original paper. Let us go back to the 1842 original work of Bowman [12]. He argued thus: “Hence must arise a greater retardation of the blood in the (glomerular) tuft, then occurs probably in any other part of the vascular system; a delay that must be increased by the tortuosity of the channels to be tranversed.” Note the words, “retardation” and “delay.” These phenomena must increase the commingling of cancer cells and red cells, i.e., the very essence of that Factor which I named as EANF.

Figure 1: Two arrowed unscathed glomeruli immersed in secondary growths.


As in other bodily curious compartments, such as the superior vena cava [7] and the spleen [13], the natural role of the Erythrocyte Associated Necrosis Factor is an explanatory hypothesis. It contributes further light on the fate of the circulating cancer cells which interested the medical masters of yester years [14]. I am persuaded that the dollar supported Translational Laboratories should be able to identify this Factor [15]. As in the old days, bleeding was the bane of mankind until the Coagulation Factor [16] was identified. And may it be so with breakthrough in EANF targeting!


  1. Onuigbo WIB (1963) An index of the fate of the circulating cancer cells. Lancet 2(7312): 828-831.
  2. Onuigbo WIB (1967) The carriage of cancer cells by the thoracic duct. Br J Cancer 21(3): 496-500.
  3. Onuigbo WIB (2013) Nature’s necrosis factor when associated with erythrocytes may not only explain the surprises in lung cancer metastasis but also suggest target therapy. Med Hypotheses 80(6): 698-700.
  4. Onuigbo WIB (2014) The scientific significance of the role of the thoracic duct in cancer cell carriage: A review. Single Cell Biol 3: 104.
  5. Onuigbo WIB (2014) Anomalous lung cancer carriage: A historical review with present prospects. Int J Surg 12(7): 734-736.
  6. Onuigbo WIB (2015) Can the hypothesized Erythrocyte Associated Necrosis Factor be applied to the prevention of metastases? J Cancer Prev Curr Res 2(6): 00062.
  7. Onuigbo WIB (2015) The superior vena cava syndrome: A Review of the history and the present prospects of target therapy. Pulm Resp Med 5: 244.
  8. Onuigbo WIB (2015) Can Immunopathology Explain Why Metastasizing Lung Cancer Cells Manifest Ubiquity in the Blood Stream but Selectivity in Lymph Node Colonization? Immunochem Immunopathol 1:110.
  9. Onuigbo WIB (2016) The occurrence of a high number of lung cancer metastases is consonant with the proposed theory of “Erythrocyte Associated Necrosis Factor. Transl BioMed 7:2.
  10. Onuigbo WIB (2016) Nature’s intrinsic “Erythrocyte Associated Necrosis Factor” (EANF) can explain cancer regression. Research Chronicle In Health Sciences 2(2): 266-268.
  11. Willis RA (1952) The spread of tumors in the human body. Butterworths, London, England, p. 197.
  12. Bowman W (1842) Structure and the use of the Malpilghean bodies of the kidney. On the observations on the circulation through the gland. Philosophical Transactions of the Royal Society of London 132(1842): 57-80.
  13. Onuigbo WIB (2016) Does the Erythrocyte Associated Necrosis Factor” explain the scarcity of metastases in the spleen? Transl Med 6: 177.
  14. Onuigbo WIB (1963) A history of the cell theory of cancer metastasis. Gesnerus 20: 90-95.
  15. Puggal MA, Schully SD, Srinivas PR, Papanicolaou GJ, Jaquish CE et al. (2013) Translation of genetics research to clinical medicine The National Heart, Lung and Blood Institute perspective. Circ Cardiovasc Genet 6(6): 634-639.
  16. Laurence DR, et al. (1987) Clinical Pharmacology, (6th Edn), Churchill Livingstone, London, England, pp. 567-570.
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