MOJ ISSN: 2373-4442MOJI

Volume 4 Issue 3 - 2016
Levels of Interleukin 4 and Immunoglobulin E in Cord Blood Umbilical Mothers of Children of Allergic
Ligia A Rodríguez A1*, Mayerling Zabala G1, Janine Tocuyo1, Ora E Pellizzeri S1 and Carmen Herrera2
1Medical Specialists, Allergology and Immunology Service Military Hospital Dr. Carlos Arvelo, USA
2Medic Specialist, Adjunct Guardian, Allergology and Immunology Service Dr. Carlos Arvelo Military Hospital, USA
Received: November 04, 2016 | Published: November 11, 2016
*Corresponding author: Ligia Rodríguez Álvarez, Deputy Immunology Institute-UCV, Calle 1 with Calle 2 and Autopista Francisco Fajardo, Las Fuentes Urbanization, El Paraíso- Caracas Venezuela, USA, Tel: 0412-2273115; Email: ;
Citation: Rodríguez LAA, Zabala MG, Tocuyo J, Pellizzeri OES, Herrera C (2016) Levels of Interleukin 4 and Immunoglobulin E in Cord Blood Umbilical Mothers of Children of Allergic. MOJ Immunol 4(3): 00127. DOI: 10.15406/moji.2016.04.00127


The development of allergic pathology occurs as a consequence of an alteration of the natural immunity, and of the mechanisms of corporal protection. Elevated levels of immunoglobulin E in umbilical cord blood have been reported to be directly related to the development of allergies in children, particularly those with a family history of allergic diseases. Our research aimed to determine the levels of Interleukin 4 and Immunoglobulin E in umbilical cord blood of healthy subjects of mothers with a history of allergy, and our link with the appearance of allergic diseases in the first trimester of life.

Of the total population studied (62), 16 subjects concluded the study, of which 12 belonged to the experimental group. We found no significant correlation between cord blood values and maternal IgE values. The main allergic manifestation in the experimental group was atopic dermatitis. We found no relation to elevated levels of IgE in cord blood with maternal which could be explained by the high specificity but low sensitivity of IgE. Subjects who had detectable levels of interleukin 4 in umbilical cord blood persisted with detectable values at 3 months of life, suggesting that these values are much more sensitive as predictors of future allergy development.

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